I have been a Pro user of flickr for some time. It has until now been the simplest way to manage, share and publish images. That is until somebody at Yahoo let their five year old have a go at designing a new interface. At best the new interface is simply unusable.
At the outset, I have to say that after much searching, there isn’t really a direct replacement for flickr. In dumping flickr you will to some extent need to review what your image hosting and sharing needs really are. It could be time to change your image workflow. If you switch from flickr this is almost certainly going to be forced on you, but it may not be such a bad thing.